Nanomedicine engineering research involves the advance of diagnostics for rapid screening and monitoring, controlled and localized drug delivery, targeted cancer therapies, enhanced cell material interactions, scaffolds for tissue engineering and gene delivery systems amongst others. Developments in nanomedicine engineering to effectively benefit patients require the interaction of diverse disciplines including chemistry, biochemistry, biophysics, engineering, materials science, cellular and molecular biology, pharmaceutical sciences and clinical translational medicine. This interdisciplinary course will address how materials are fabricated and characterized, and how they interact in biological systems. The emphasis of the course will be in the application of therapeutics and controlled release drug delivery systems. Integration of biomaterial nanostructures and release analysis will be highlighted throughout the course. Through lectures, paper reviews, class discussions, experimental lab exposure, class presentations and homework assignments, students will develop an in-depth understanding of the various ways nanoparticles have been used as diagnostics tools, in advancing tissue engineering and in how drug delivery systems can be improved to overcome the problems associated with typical oral and intravenous administration. Several types of drug and gene delivery methods, including oral, transdermal, implantable, targeted and pulmonary, will be discussed. The course will highlight the rational design of drug delivery devices based on the fundamental understanding in engineering, pharmacology, chemistry and biomaterials science. Concurrent with CHEE 489.