Roberto Guzmán
Dr. Roberto Guzmán has been a chemical engineering professor at the University of Arizona since 1989. He has faculty joint appointments in biomedical engineering and in pharmacology and toxicology at the University of Arizona. He also has an academic appointment as an international faculty in the Nanotechnology Program at the University of Sonora, Mexico. He has been a visiting professor at the University of Guanajuato, Mexico, at the University of Uppsala, Sweden and at the University of Technology in Compiegne, France, where he also has a visiting scholar appointment. He received a PhD in chemical engineering/biotechnology from North Carolina State University (NCSU) where he continued as a postdoc for a year before joining the University of Arizona. He received an MSc in chemical engineering from the University of Illinois, Chicago and a BS in chemical engineering from the University of Guanajuato, Mexico. His present research is in nanoparticle bio/technology and protein purifications with emphasis in metal-hybrid nanoparticles for diagnostics and target drug delivery therapy and discovery of biomarkers from biological fluids. Professor Guzman background has strong bases in molecular recognition, affinity technology, synthetic chemistry, applied biochemistry and mathematical modeling. The areas of research studied in his laboratory fall in the boundaries between synthetic chemistry, biology, medicine, polymer sciences and engineering and incorporate both experimental and theoretical work analysis.
Degrees
- PhD Chemical Engineering -- Biotechnology
- North Carolina State University, Raleigh, North Carolina, United States
- Affinity Purification of Biomolecules Using Ligand-Modified Surfactants
- MS Chemical Engineering -- Catalysis
- University of Illinois, Chicago, Illinois, United States
- Study of Catalytic Combustion for NOx Emission Control.
- BS Chemical Engineering
- Univers ty of Guanajuato, Guanajuato, Gto, Mexico
- Treatment of Residual Waters in a Caprolactham and Ammonium Sulfate Chemical Plant.
Work Experience
- University of Arizona, Tucson, Arizona (1989 - Ongoing)
Interests
Teaching
Have developed seminar series, in biotechnology for undergraduate students from different disciplines relevant to engineering and its interaction with biotechnology. These students eventually get involved in research activities in laboratories throughout the university. Have developed new courses in Nanomedicine Engineering, Nanomaterials in Drug Delivery and have modify a Bioprocessing course to include novel biomaterials and bioprocessing fields of interest and broader impact.
Research
Research Contributions and InnovationsThe main Research Interest in my research group has been the development of novel biomedical nanoparticle platforms for drug delivery, imaging and therapy. Main topics include: 1. Nano/biomolecular polymeric structures with encapsulated anticancer drugs and gold shells for dual cancer therapy that combines controlled and targeted drug delivery and infrared thermal ablation. 2. Nano/biomolecular multifunctional para-magnetic metal-hybrid nanoparticles for diagnostics and target NIR therapy. We are now developing novel Nanoparticle Bioconjugates for Combination Therapy of Lung, Pancreatic and Breast cancer. We are also developing novel multifunctional magnetic nanoparticles for biodiagnostics and novel therapeutic applications. 3. Development of novel specific adsorbents for low molecular weight biomarkers isolation and identification. Technology could be used not only for cancer biomarkers but potentially for any other disease that produces extraneous biomolecules.
Courses
Independent Study
CHEE 299 (Fall 2018)
CHEE 299 (Spring 2018)
CHEE 399 (Fall 2022)
CHEE 399 (Spring 2022)
CHEE 399 (Fall 2019)
CHEE 399 (Spring 2019)
CHEE 399 (Spring 2018)
CHEE 399 (Fall 2016)
CHEE 499 (Spring 2022)
CHEE 499 (Fall 2021)
CHEE 499 (Spring 2020)
CHEE 499 (Fall 2019)
CHEE 499 (Spring 2019)
CHEE 499 (Fall 2018)
CHEE 499 (Spring 2017)
CHEE 499 (Fall 2016)
CHEE 599 (Fall 2023)
CHEE 599 (Spring 2020)
CHEE 599 (Fall 2019)
CHEE 599 (Fall 2016)
Directed Research
BIOC 392 (Spring 2019)
BIOC 392 (Fall 2018)
BIOC 492 (Fall 2019)
BIOC 492 (Summer I 2019)
BME 492 (Spring 2022)
CHEE 392 (Spring 2024)
MCB 792 (Spring 2022)
Honors Independent Study
CHEE 399H (Spring 2022)
CHEE 399H (Fall 2019)
CHEE 499H (Fall 2021)
CHEE 499H (Spring 2021)
CHEE 499H (Fall 2020)
MCB 399H (Fall 2023)
Chemical Engineer Mdling
CHEE 402 (Fall 2023)
CHEE 402 (Fall 2022)
Electrochemical Engineering
CHEE 412 (Fall 2017)
CHEE 512 (Fall 2017)
Engr/Biological Process
ABE 481A (Fall 2018)
ABE 481A (Fall 2017)
ABE 581A (Fall 2018)
ABE 581A (Fall 2017)
BE 481A (Spring 2022)
BE 481A (Spring 2021)
BE 481A (Fall 2019)
BE 581A (Spring 2023)
BE 581A (Spring 2021)
BE 581A (Fall 2019)
CHEE 481A (Spring 2023)
CHEE 481A (Spring 2022)
CHEE 481A (Spring 2021)
CHEE 481A (Fall 2019)
CHEE 481A (Fall 2018)
CHEE 481A (Fall 2017)
CHEE 581A (Spring 2023)
CHEE 581A (Spring 2022)
CHEE 581A (Spring 2021)
CHEE 581A (Fall 2019)
CHEE 581A (Fall 2018)
CHEE 581A (Fall 2017)
Nanomedicine Eng. in Drug Deli
CHEE 489 (Spring 2022)
CHEE 489 (Spring 2021)
CHEE 489 (Spring 2019)
CHEE 489 (Spring 2018)
CHEE 489 (Spring 2017)
CHEE 489 (Spring 2016)
Senior Capstone
BIOC 498 (Spring 2024)
BIOC 498 (Fall 2023)
BIOC 498 (Spring 2020)
BIOC 498 (Fall 2019)
Honors Thesis
BIOC 498H (Spring 2023)
BIOC 498H (Fall 2022)
Introduction to Pharmacology
PCOL 501 (Fall 2023)
PCOL 501 (Fall 2022)
PCOL 501 (Fall 2021)
PCOL 501 (Fall 2020)
PHSC 501 (Fall 2022)
PHSC 501 (Fall 2021)
PHSC 501 (Fall 2020)
Adv Engineering Analysis
CHEE 502 (Fall 2023)
CHEE 502 (Fall 2022)
CHEE 502 (Fall 2021)
CHEE 502 (Fall 2020)
CHEE 502 (Fall 2019)
CHEE 502 (Fall 2018)
CHEE 502 (Fall 2017)
CHEE 502 (Fall 2016)
Nanomedicine Eng. in Delivery
CHEE 589 (Spring 2021)
CHEE 589 (Spring 2019)
CHEE 589 (Spring 2018)
CHEE 589 (Spring 2017)
CHEE 589 (Spring 2016)
Rsrch Meth Biomed Engr
BME 592 (Fall 2023)
Pharmaceutics Research
PHSC 596C (Fall 2023)
PHSC 596C (Spring 2023)
PHSC 596C (Fall 2022)
PHSC 596C (Spring 2022)
PHSC 596C (Fall 2021)
PHSC 596C (Spring 2021)
PHSC 596C (Fall 2020)
Chemical Engineering
CHEE 696A (Spring 2020)
CHEE 696A (Fall 2019)
CHEE 696A (Spring 2019)
CHEE 696A (Fall 2018)
CHEE 696A (Spring 2018)
CHEE 696A (Spring 2017)
CHEE 696A (Fall 2016)
CHEE 696A (Spring 2016)
Research
CHEE 900 (Spring 2024)
CHEE 900 (Fall 2023)
CHEE 900 (Spring 2023)
CHEE 900 (Fall 2022)
CHEE 900 (Spring 2022)
CHEE 900 (Fall 2021)
CHEE 900 (Spring 2021)
CHEE 900 (Fall 2020)
CHEE 900 (Spring 2020)
CHEE 900 (Fall 2019)
CHEE 900 (Fall 2017)
CHEE 900 (Spring 2017)
CHEE 900 (Spring 2016)
PHSC 900 (Spring 2023)
PHSC 900 (Spring 2022)
PHSC 900 (Fall 2021)
PHSC 900 (Spring 2021)
Master's Report
BME 909 (Spring 2024)
CHEE 909 (Fall 2016)
Thesis
CHEE 910 (Spring 2024)
CHEE 910 (Fall 2023)
CHEE 910 (Spring 2023)
CHEE 910 (Fall 2022)
CHEE 910 (Spring 2022)
CHEE 910 (Fall 2021)
CHEE 910 (Spring 2019)
CHEE 910 (Fall 2018)
CHEE 910 (Spring 2018)
CHEE 910 (Fall 2017)
CHEE 910 (Spring 2017)
CHEE 910 (Fall 2016)
CHEE 910 (Spring 2016)
Dissertation
BME 920 (Fall 2018)
BME 920 (Spring 2018)
BME 920 (Fall 2017)
BME 920 (Spring 2017)
BME 920 (Fall 2016)
CHEE 920 (Spring 2024)
CHEE 920 (Fall 2023)
CHEE 920 (Spring 2023)
CHEE 920 (Fall 2022)
CHEE 920 (Spring 2022)
CHEE 920 (Fall 2021)
CHEE 920 (Spring 2021)
CHEE 920 (Fall 2020)
CHEE 920 (Spring 2020)
CHEE 920 (Fall 2019)
CHEE 920 (Spring 2019)
CHEE 920 (Fall 2018)
CHEE 920 (Spring 2018)
CHEE 920 (Fall 2017)
CHEE 920 (Summer I 2017)
CHEE 920 (Spring 2016)
PHSC 920 (Spring 2024)
PHSC 920 (Spring 2023)
PHSC 920 (Fall 2022)
Selected Publications
Journals/Publications
- Guzmán, R. Z. (2019). Biosynthesis of gold and silver nanoparticles using Parkinsonia florida leaf extract and antimicrobial activity of silver nanoparticles. Materials Research Express, 6(9), 1-12. doi:doi.org/10.1088/2053-1591/ab2d8e
- Guzmán, R. Z. (2019). Differential Response of BEAS-2B and H-441 Cells to Methylene Blue Photoactivation. ANTICANCER RESEARCH, 39(1), 3739-3744. doi:doi:10.21873/anticanres.13522
- Guzmán, R. Z. (2019). Mathematical modeling and parametrical analysis of the temperature dependency of control drug release from biodegradable nanoparticles. RSC Adv., 9(1), 8728. doi:DOI: 10.1039/c9ra00821g
- Guzmán, R. Z. (2019). Mathematical modeling and parametrical analysis of the temperature dependency of control drug release from biodegradable nanoparticles. Royal Society of Chemistry. doi:DOI: 10.1039/c9ra00821g
- Guzmán, R. Z. (2019). Substrate-source flexibility of an exponential-fed perfusion process to produce plasmid DNA for use as leishmaniasis vaccine. Biotechnology & Biotechnological Equipment,, on line, 16. doi:https://doi.org/10.1080/13102818.2018.1560232
- Guzmán, R. Z. (2019). Substrate-source flexibility of an exponential-fed perfusion process to produce plasmid DNA for use as leishmaniasis vaccine. Biotechnology & Biotechnological Equipment, 33(1), 195-203. doi:DOI: 10.1080/13102818.2018.1560232
- Guzmán, R. Z. (2018). Enhancement of pDNA Uptake and Expression in H441 Cells by Using PLGA Nanocarriers.. Microscopy and Microanalysis, 24(S1), 1414-1415. doi:doi:10.1017/S1431927618007559.
- Guzmán, R. Z. (2018). Evaluation of a combined emulsion process to encapsulate methylene blue into PLGA nanoparticles. RSC Adv, 8, 414 - 422. doi:DOI: 10.1039/c7ra12296a
- Guzmán, R. Z. (2018). Hollow Gold Nanoshells Encapsulated in PNIPAM Nanoparticles. Microscopy and Microanalysis, 24(S1), 1794-1795. doi:doi:10.1017/S1431927618009455
- Guzmán, R. Z. (2018). Mathematical modeling of the batch adsorption of proteins on new restricted access media with poly(ethylene glycol) as a semi-permeable barrier using compact finite differences. Brazilian Journal of Chemical Engineering., 35(1), 237–251. doi:dx.doi.org/10.1590/0104-6632.20180351s20160404.
- Guzmán, R. Z. (2018). Plasmid-DNA lipid nanovaccines: An innovative approach for a better world health. In Lipid Nanocarriers for Drug Targeting. 2019 Elsevier Inc., 232-267. doi:http://dx.doi.org/10.1016/B978-0-12-813687-4.00006-2
- Guzmán, R. Z. (2018). Plasmid-DNA lipid nanovaccines: An innovative approach for a better world health. Lipid Nanocarriers for Drug Targeting-Book. doi:http://dx.doi.org/10.1016/B978-0-12-813687-4.00006-2
- Guzmán, R. Z. (2017). Aqueous-Organic Phase Transfer of Gold and Silver Nanoparticles Using Thiol-Modified Oleic Acid. Applied Sciences. doi:10.3390/app7030273
- Guzmán, R. Z. (2017). Evaluation of a combined emulsion process to encapsulate methylene blue into PLGA nanoparticles.. Royal Society of Chemistry.
- Guzmán, R. Z. (2017). Performance analysis of exponential-fed perfusion cultures for pDNA vaccines production. Journal of Chemical Technology and Biotechnology, 92(2), 342–349.
Poster Presentations
- Guzmán, R. Z., & Garcia-Soto, M. (2017, June). Gold derivatized nanocomposites for the effective detection, contrast imaging and thermal ablation in cancer research. AFFINITY 2017. The 22th Meeting of the International Society for Molecular RecognitionInternational Society for Molecular Recognition.
- Guzmán, R. Z., & Lucero, A. A. (2017, June). Polymeric nanoparticles for controlled drug delivery: Synthesis, modeling and application in vitro and in vivo to pancreatic cancer. AFFINITY 2017. The 22th Meeting of the International Society for Molecular Recognition. Paris, France: International Society for Molecular Recognition.
- Guzmán, R. Z., Yan, S., & Wang, L. (2017, June). Affinity chelating liposomes for protein separations and effect of PEG on aggregation and binding interactions. AFFINITY 2017. The 22th Meeting of the International Society for Molecular Recognition. Paris, France: International Society for Molecular Recognition.
- Guzmán, R. Z., Zheng, X. J., Cheung, L. S., Wang, L., Baygents, J. C., Schroeder, J. A., Heimark, R. L., & Zohar, Y. (2017, June). Antibody-functionalized microfluidic chamber arrays for specific binding of metastatic breast cancer cells. AFFINITY 2017. The 22th Meeting of the International Society for Molecular Recognition. Paris, France: International Society for Molecular Recognition.
Presentations
- Guzmán, R. Z. (2017, June). Affinity Adsorption Chromatography Modulated by Polymer Permeation Control. A strategy to purify peptides and small proteins. AFFINITY 2017. The 22th Meeting of the International Society for Molecular Recognition. Paris, France: International Society for Molecular Recognition.
- Guzmán, R. Z. (2017, May). Nanotecnología y Nanopartículas en Aplicaciones Biomédicas. Terapias Especificas para el Tratamiento de Cáncer. 4rd International Biotechnology Congress at Universidad Popular Autónoma del Estado de Puebla (UPAEP). Puebla, Pue., México.: Universidad Popular Autónoma del Estado de Puebla (UPAEP).
- Guzmán, R. Z. (2017, October). Cancer Nanotechnology –Current Status and Future Opportunities–Perspectives from the NCI Alliance for Nanotechnology in Cancer. 2017 Annual Nanomaterials and Nanotechnology Symposium at the Universidad de Sonora. Hermosillo, Sonora Mexico: Departement of Physics, Universidad de Sonora.
- Guzmán, R. Z. (2017, October). Nanotechnology and Biomedical Applications. Nanoparticles in Diagnostics and Specific Therapies for Cancer Treatment. 2017 Annual Nanomaterials and Nanotechnology Symposium at the Universidad de Sonora. Hermosillo, Sonora, Mexico.: Departement of Physics, Universidad de Sonora.
- Guzmán, R. Z. (2017, September). Control Drug Delivery with Polymeric Nanoparticles”. 2do Simposio de Ingeniería de Procesos, Universidad Veracruzana. Xalapa, Veracruz, México: Universidad Veracruzana, Xalapa, Veracruz, México.
- Guzmán, R. Z. (2017, September). La Ingenieria Quimica/Bioquimica y Nanobiotecnologia. Tendencias, Oportunidades y Aplicaciones in Biomedicina. 6to Simposio Nacional de Ingeniería Química y Bioquímica Aplicada (SNQBA 2017). Tlaxcala, Tlaxcala. México: Universidad Autónoma de Tlaxcala.